Abstract

 Resveratrol and quercetin, two natural polyphenolic compounds, exhibit potential in veterinary and human medicine for cardiovascular benefits, particularly for the prevention and management of restenosis, a complex process involving blood vessel re-narrowing. This review investigates the impact of these compounds on restenosis in animal models, explaining their modes of action, which include antioxidant, anti-inflammatory, and anti-proliferative capabilities. Additional insights are provided by the intriguing "French Paradox," in which the Southern French population's low heart disease incidence is associated with red wine and polyphenol-rich diet consumption. Through animal models, we gain essential knowledge about the therapeutic potential, safety, and dosing of resveratrol and quercetin in both veterinary and human clinical settings. Understanding their precise molecular pathways is essential in enhancing their effectiveness in reducing restenosis. The "French Paradox" draws attention to the potential cardiovascular benefits of polyphenols in restenosis. Novel approaches to minimize restenosis in veterinary and human medicine may result from bridging the gap between animal models and human trials.
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