“Deciphering the enigmatic role of gamma-aminobutyric acid (GABA) in plants: Synthesis, transport, regulation, signaling, and biological roles in interaction with growth regulators and abiotic stresses.”

Abstract

Gamma-aminobutyric acid (GABA) is an amino acid with a four-carbon structure, widely distributed in various organisms. It exists as a zwitterion, possessing both positive and negative charges, enabling it to interact with other molecules and participate in numerous physiological processes. GABA is widely distributed in various plant cell compartments such as cytoplasm mitochondria, vacuoles, peroxisomes, and plastids. GABA is primarily synthesized from glutamate using glutamate decarboxylase and participates in the GABA shunt within mitochondria, regulating carbon and nitrogen metabolism in plants The transport of GABA is regulated by several intracellular and intercellular transporters such as aluminium-activated malate transporters (ALMTs), GABA transporters (GATs), bidirectional amino acid transporters (BATs), and cationic amino acid transporters (CATs). GABA plays a vital role in cellular transformations, gene expression, cell wall modifications, and signal transduction in plants. Recent research has unveiled the role of GABA as a signaling molecule in plants, regulating stomatal movement and pollen tube growth. This review provides insights into multifaceted impact of GABA on physiological and biochemical traits in plants, including cellular communication, pH regulation, Krebs cycle circumvention, and carbon and nitrogen equilibrium. The review highlights involvement of GABA in improving the antioxidant defense system of plants, mitigating levels of reactive oxygen species under normal and stressed conditions. Moreover, the interplay of GABA with other plant growth regulators (PGRs) have also been explored.