Abstract
Cultured astrocytes contain immunologically specific aromatic l-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with l-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of dopamine was blocked by NSD-1015. These experiments show that mouse cultured astrocytes are capable to convert l-Dopa into dopamine in a dose-dependent fashion.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call