Abstract
Hepatocellular Carcinoma (HCC) is one of the most fatal cancers, whose incidence and death rates are still rising. Here, we report the identification of long non-coding RNAs (IncRNAs) that associated with HCC progression and metabolism based on the systematically analysis of large scale RNA-seq data from HCC patients. We identified seven lncRNAs with high confidence which were highly related with prognostic of HCC. Of note, three of them had quite different expression patterns between the control samples and the patients, and their critical roles in cancer progression were validated. We proposed that DDX11-AS1 play important role during HCC oncogenesis and may serve as potential therapy target for HCC.
Highlights
It was estimated that there would be over 39,000 new hepatocellular cancer (HCC) cases and over 27,000 deaths caused by it in the United States in 2016 [1]
1736 Long non-coding RNA (lncRNA) were differentially expressed between the control sample and the patients with a p value less than 0.01 (Figure 1B), where 452 lncRNAs were highly expressed in the control samples and 1284 were highly expressed in patients
The Q-Q plot was shown in Figure 1C, which indicated that many more lncRNAs were significantly differentially expressed compared with random situation
Summary
It was estimated that there would be over 39,000 new hepatocellular cancer (HCC) cases and over 27,000 deaths caused by it in the United States in 2016 [1]. Studies have indicated that dysregulated expression of lncRNAs had impacts on the capacities of cancer cells for tumor initiation, growth, and metastasis, which served them as promising targets for cancer diagnosis and therapy [2]. There were only several lncRNAs that have been functionally annotated, the majority still remains to be characterized. Different high-throughput methods to identify new lncRNAs (including RNA sequencing and annotation of chromatin-state maps) have been applied in various studies searching the potential therapy target for cancers. The potential role of lncRNAs that play in the progress of HCC remains unknown. Identification of the critical lncRNAs which associated the LHC would provide new insight for discovery of new therapy
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