Abstract
Cancer predisposition genes (CPGs) are genes in which inherited mutations confer highly or moderately increased risks of developing cancer. Identification of these genes and understanding the biological mechanisms that underlie them is crucial for the prevention, early diagnosis, and optimized management of cancer. Over the past decades, great efforts have been made to identify CPGs through multiple strategies. However, information on these CPGs and their molecular functions is scattered. To address this issue and provide a comprehensive resource for researchers, we developed the Cancer Predisposition Gene Database (dbCPG, Database URL: http://bioinfo.ahu.edu.cn:8080/dbCPG/index.jsp), the first literature-based gene resource for exploring human CPGs. It contains 827 human (724 protein-coding, 23 non-coding, and 80 unknown type genes), 637 rats, and 658 mouse CPGs. Furthermore, data mining was performed to gain insights into the understanding of the CPGs data, including functional annotation, gene prioritization, network analysis of prioritized genes and overlap analysis across multiple cancer types. A user-friendly web interface with multiple browse, search, and upload functions was also developed to facilitate access to the latest information on CPGs. Taken together, the dbCPG database provides a comprehensive data resource for further studies of cancer predisposition genes.
Highlights
Cancer, as the second leading cause of death, is a major public health problem in the world
In the ‘Methylation’ category, we used the textual interfaces to depict the methylation information, which were obtained from DiseaseMeth database [13]
For each Cancer predisposition genes (CPGs), we offered its involved pathways in the ‘Pathway’ category, which were obtained from MSigDB [17]
Summary
As the second leading cause of death, is a major public health problem in the world. It is estimated that there are 1,658,370 new cancer cases and 589,430 cancer deaths in the United States in 2015 [1]. At least 3% of all cancers are hereditary, meaning a germline pathogenic mutation can contribute to cancer development [2]. Genes in which germline mutations increase the risks of developing cancer are called cancer predisposition genes (CPGs) [2]. Most CPGs act as tumor suppressors with mutations that abolish their function and contribute to the development of a cancer, only a few CPGs predisposed to cancer is the result of gain-of-function mutations [2]. It was estimated that around 5–10% of breast cancers are due to germline mutations in CPGs such as BRCA1 and BRCA2 [4], while lung cancers are thought to be more strongly related to environment components
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
