Abstract
Medicinal plants are identified and used throughout human history; it has a great economic value especially in drugs discovery. Date palm pollen (DPP) is used traditionally in Sudan for treating sub-fertile male patients. Male infertility is heterogeneous group of disorders, most of them are idiopathic. This study is aimed to investigate the role of pharmaceutical preparation of DPP in amelioration of male sub fertility with detection of any possible adverse effects on the major body system functions, through blood picture, liver enzymes and kidney function. This study is a single group pretest-posttest experimental prospective comparative self-control. Sub-fertile men with Idiopathic oligoasthenozoospermia or azoospermia were received 500 mg capsules of DPP twice daily for three months after conducting their safety profiles to detect any toxic effects on hematological, hepatological and nephrological functions, Blood samples were taken from the patients for serum level of FSH (for azoospermic patients), FSH and Testosterone (for oligoasthenozoospermic patients). Finally, Semen sample have been obtained for computerized assisted semen analysis (CASA) report I and II. DPP administration induced significant increase (p≤0.001) in testosterone level (in oligoasthenozoospermic patients) and FSH level (in azoospermic patients). DPP induced significant changes (p≤0.001) towards improvement in the total and progressive sperm motility percentages measured in oligoasthenozoospermic patients by CASA dynamic analysis report I and II. The toxicological studies for DPP approved their safety use in human.
Highlights
Infertility is defined as the failure to conceive after regular unprotected intercourse for two years in the absence of known reproductive pathology [1], reflected by defective spermatogenesis due to pituitary disorders, testicular cancer, germ cell aplasia, varicocele, and environmental factors, or due to defective sperm transport resulting from congenital abnormalities, immunological or neurological factors or could be caused by increased incidence of genetic disorders and apoptosis [2].Oligoasthenozoospermia is characterized by abnormal semen quality with multiple sperm defects [3], while azoospermia is characterized by absent of sperm in the semen [4,5]
Sub-fertile men with Idiopathic oligoasthenozoospermia or azoospermia were received 500 mg capsules of Date palm pollen (DPP) twice daily for three months after conducting their safety profiles to detect any toxic effects on hematological, hepatological and nephrological functions, Blood samples were taken from the patients for serum level of FSH, FSH and Testosterone
DPP induced significant changes (p≤0.001) towards improvement in the total and progressive sperm motility percentages measured in oligoasthenozoospermic patients by computerized assisted semen analysis (CASA) dynamic analysis report I and II
Summary
Infertility is defined as the failure to conceive after regular unprotected intercourse for two years in the absence of known reproductive pathology [1], reflected by defective spermatogenesis due to pituitary disorders, testicular cancer, germ cell aplasia, varicocele, and environmental factors, or due to defective sperm transport resulting from congenital abnormalities, immunological or neurological factors or could be caused by increased incidence of genetic disorders and apoptosis [2].Oligoasthenozoospermia is characterized by abnormal semen quality with multiple sperm defects [3], while azoospermia is characterized by absent of sperm in the semen [4,5]. There are few studies on infertility in sub-Saharan Africa, which tend to lack of research due to economic reasons and, possibly, the psychological denial of the problem [8,9]. Most empiric therapies in male sub fertility are hormonal and based upon the theory that increasing the amount of circulating testosterone and\or FSH will improve testicular function, spermatogenesis [10,11]. Non endocrine treatments aimed to improve the quality of semen have been tested or are currently being evaluated; these treatments are varied and include those possible benefits and those without proved effect.Thyroxine, argenine [12], corticosteroids [13], antibiotics [14], methylyxanthines [15] and vitamins (as vitamin B12, A,E and C) have all been studied [16,17,18]. Non pharmacological treatments (Elimination of toxic factors and thermal stress, surgical treatments, assisted reproductive technology) are used [19]
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