Abstract
Background: The use of minerals in treatment of different diseases is as old as man himself. zinc is the most famous trace mineral related to male sexual function. Oligoasthenozoospermic subfertile patients were treated with zinc sulphate for three months.
 Objectives: Aim of the research is to investigate the role of Zinc and if it affects the abnormalities of some semen parameters and to study the possible role of pharmaceutical preperations of zinc in amelioration of male subfertility as well as to assess the ability of Zinc to induce changes in the serum and semen zinc levels in addition to the levels of reproductive hormones (FSH and Testosterone).
 Type of the study: The study is a single group pretest-posttest experimental prospective comparative self-control; clinical trial research.
 Methods: The patients were tested before and after the treatment for semen analysis via Computerized Assisted Semen Analysis (CASA) dynamic analysis report I and II as well as for FSH and Testosterone hormonal levels, serum and semen zinc levels .
 Results: Zinc administration induced a significant increase(p≤0.001) in FSH, Testosterone, serum and semen zinc level as well as in the total and progressive sperm motility percentages .
 Conclusions: Zinc administration induced significant changes (p≤0.001) towards improvement in the total and progressive sperm motility percentages in oligoasthenozoospermic patients by CASA dynamic analysis report I and II.
Highlights
The use of minerals in treatment of different diseases is as old as man himself. zinc is the most famous trace mineral related to male sexual function
The treatment induced a significant change in FSH after zinc administration, this is in contrary to the finding of other studies[25,26], which showed no change in serum FSH level in sub-fertile patients after zinc therapy
Testosterone 340.6 ng/dl changed to be 475.9 ng/dl, this is in agreement with the finding of a previous study[25], which occurred because testosterone synthesis is zinc dependent[28]
Summary
Male infertility is a complex medical problem, and has multiple causes and consequences depending on the general health state, sexual history, life style of society and cultural background of people it affects[20]. Immotile spermatozoa percentage (IM% Class D) has dropped in a statistically significant value (p 0.001), from 84.31 % in the pretreatment measure to 62.39% in the post treatment (table 4), which is regarded as a good sign of general sperm motility improvement These results can be explained in agreement with some studies which show that most of zinc in the seminal fluid is in binding state to ligands, from prostate such as metallothionein and prostasomes (prostasomes are present in the seminal fluid and adhering to the surface of the spermatozoa and it contains zinc dependent ATPase that involved in sperm motility) [38]. Effects of zinc treatment on sperm tracks and velocities measured in oligoasthenozoospermic patients stated by CASA dynamic parameter analysis report II: [both average path velocity (VAP), straight-line velocity (VSL) after zinc administration for three months increased in a statistically significant value (p 0.001)]. Both the progressive linear motility (VSL) and the vigorous nonlinear non- progressive motion (VCL) are of high importance[48], in our current study both increased and improved by the administration of zinc in oligoasthenozoospermic patients
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