Abstract
Data on the allele, genotype and haplotype frequencies of the five single nucleotide polymorphisms (SNPs) such as rs1063192, rs7865618, rs2157719, rs944800 and rs4977756 of the CDKN2B-AS gene in Russian patients with primary open-angle glaucoma (POAG) are provided. These SNPs are found to be associated with the risk of POAG by genome-wide association studies (GWAS). The frequencies of alleles, genotypes and haplotypes of CDKN2B-AS gene were present separately for entire group of patients, females and males, and may be used as reference data of Russian population.
Highlights
Dataset of allele, genotype and haplotype frequencies of five polymorphisms CDKN2B-AS1 gene in Russian patients with primary open-angle glaucoma
Genotype and haplotype frequencies of the five single nucleotide polymorphisms (SNPs) such as rs1063192, rs7865618, rs2157719, rs944800 and rs4977756 of the CDKN2B-AS gene in Russian patients with primary openangle glaucoma (POAG) are provided. These SNPs are found to be associated with the risk of POAG by genome-wide association studies (GWAS)
Biology Genetics Table MALDI/TOF mass spectrometry using Sequenom MassARRAY 4.0 platform (Agena BioscienceTM ) Raw and analyzed data About 5 ml of whole blood was collected from each study subject into a plastic vial (Vacutainer®) with 0.5M EDTA
Summary
The dataset represents the raw data (supplementary Table), frequencies of alleles, genotypes (Table 1) and haplotypes (Table 2) for five SNPs (rs1063192, rs7865618, rs2157719, rs944800 and rs4977756) of the CDKN2B-AS gene in Russian patients with POAG. These SNPs are found to be associated with the risk of POAG in previously published GWAS (Table 3) [1,2,3,4,5,6,7,8,9,10]. The frequencies of alleles, genotypes and haplotypes for the SNPs are provided separately for three groups: entire sample, females and males. No significant differences in the allele, genotype and haplotype frequencies were found between the males and females groups
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