Danqi Granules Combined with Alfacalcidol Tablets in the Treatment of Senile Osteoporosis and its Effect on Bone Metabolism and Cytokines

Abstract

Background This study investigated the effect of Danqi granules combined with alfacalcidol tablets in the treatment of senile osteoporosis and its influence on bone metabolism and cytokines, in order to provide reference for the clinical treatment of senile osteoporosis. Methods: A total of 130 patients with senile osteoporosis admitted to our hospital from January 2018 to January 2020 were selected and divided into control group and observation group according to a random number table method, with 65 cases in each group. Patients in Control group were treated with alfacalcidol tablets, and patients in observation group were treated with Danqi granules combined with alfacalcidol tablets. The clinical efficacy, bone metabolism, cytokines, joint dysfunction, pain, quality of life and occurrence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of observation group was obviously higher than that of control group (P<0.05); after treatment, the levels of alkaline phosphatase (ALP), anti-tartrate acid phosphatase (TRACP-5b), type I collagen C-terminal peptide (β-CTX) and tumor necrosis factor-α (TNF-α) levels in two groups were obviously lower than those before treatment (P<0.05), and those of observation group were obviously lower than those of control group (P<0.05). After treatment, the levels of insulin-like growth factor (IGF-I) and transforming growth factor-β (TGF-β1) in the two groups were obviously higher than those before treatment (P<0.05), and those of observation group were obviously higher than those of control group (P<0.05). After treatment, the scores of oswestry dysfunction index (ODI) and visual analog scale (VAS) in the two groups were obviously lower than those before treatment (P<0.05), and those in observation group were obviously lower than those in control group (P<0.05). After treatment, the score of the MOS item short from health survey (SF-36) in the two groups was obviously higher than that before treatment (P<0.05), and that of observation group was obviously higher than that of control group (P<0.05). The adverse reaction rate in observation group was obviously lower than that in control group (P<0.05). Conclusion: Danqi granules combined with alfacalcidol tablets achieved a significant efficacy in treatment of senile osteoporosis, which could effectively relieve pain, regulate bone metabolism, ameliorate dysfunction and improve quality of life of patients with a safe and reliable effect.