Damage to the structures of the brain in acute carbon monoxide poisoning

Abstract

The aim of the study was to investigate the features of damage to the structures of the brain in acute carbon monoxide (CO) poisoning. The results of forensic, microscopic and morphometric studies of the brain of 78 corpses died from acute carbon monoxide poisoning are presented. The peculiarities of damage to the nervous tissue, the glial complex, as well as changes in the structures of blood vessels and the state of intravascular blood with the formation of aggregates, sludge, and blood clots were revealed. These changes along with perivascular and pericellular edema indicate the agonal death of the victims. When the carboxyhemoglobin concentration in the blood is about 30% the brain structures' lesions begin to appear; their intensity increases when the carboxyhemoglobin concentration is more than 60%. According to the authors, the substantiation of the thanatogenesis of various types of carbon monoxide poisoning requires further research taking into account the age of the victims, the carboxyhemoglobin concentration in the blood, the duration of the agonal period, as well as possible (competing) conditions: for example, acute alcohol intoxication, thermal injury, etc. Still urgent the studies of structures of other target organs of CO - heart and lungs.