Daily green tea extract supplementation reduces prothrombotic and inflammatory states in dialysis patients

Abstract

Cardiovascular disease (CVD) remains the most common cause for excess morbidity and mortality in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD) under chronic dialysis. ESRD patients have increased oxidative stress and endothelial dysfunction alongside increased levels of inflammation related proteins, which has prompted the exploration of anti-inflammatory and antioxidant treatments to improve outcomes. As green tea is increasingly well recognized for its antioxidant properties, we probed the effect of consumption of 1 capsule daily of green tea as a commercially available, decaffeinated green tea capsule (1g, catechin content 68mg) for 6months on fibrinogen and inflammation in dialysis patients. Chronic hemodialysis patients (N=25) were recruited and fibrinogen, FDP-D-dimer, high sensitivity (hs) CRP and the mononuclear cell protein expression of p22phox, were assessed before, i.e. baseline and after 6months of ingestion of 1 green tea capsule per day. After 6months of daily green tea capsule ingestion, dialysis patients showed reduced protein expression of p22phox (p<0.0001), reduced hsCPR (p=0.032) and fibrinogen (p=0.022) levels and increased FDP-D-dimer (p=0.0019) compared to their values at baseline. These results document lower oxidative stress and inflammation with green tea capsule ingestion and suggest a likely positive impact of green tea treatment on the atherosclerotic process of ESRD patients under dialysis.