Abstract
Background: Anti-cancer effects of medicinal plant products are mentioned in the ancient texts of Ayurveda. Currently, they have been studied at experimental and clinical levels in reverse pharmacology mode. Tinospora cordifolia wild is the most widely used for its medicinal properties in Ayurveda. It has been reported for having anticancer potential in many cancers. 
 Aim: The aim of the study is to explore the anticancer potential of Tinospora cordifolia Wild extracts against human kidney cancer cell lines. 
 Materials and Methods: Methanolic extracts leaf and stem of Tinospora cordifolia were obtained by soxhlet extraction. Both the extracts were analyzed for phytochemical screening. Both the extracts along with marker berberine were assessed for their cytotoxicity using the sulforhodamine B assay method against a 786-O human renal cell carcinoma cell line. Statistical analysis was done by Two way (ANOVA) followed by Bonferroni’s Post hoc test. 
 Results: Tinospora Cordifolia leaf and stem extracts and berberine showed highly significant cytotoxic activity as compared to control.
 Conclusion: Therefore, Tinospora cordifolia can be considered as a potential medicinal plant with anticancer activity against human kidney cancer.
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