An Overview of Self Nano-emulsifying Drug Delivery Systems for Enhanced Solubility and Dissolution for Anti-cancer Drugs

Abstract

The current review aims to explore recently identified chemical compounds, particularly focusing on the challenge posed by the poor water solubility of many existing drug molecules. This limitation significantly affects the successful development and marketability of new pharmaceuticals, as the dissolution phase often becomes the bottleneck in the process. Crafting formulations becomes crucial in enhancing the absorption and, consequently, the oral effectiveness of these drug prospects. Given the prevalence of various diseases such as cancer, AIDS, HIV, and chronic inflammation among humans, optimizing drug delivery methods becomes pivotal to achieving maximum therapeutic benefits with minimal side effects. Innovative drug delivery systems like self-nano-emulsion are introduced, offering protective measures for medications, augmenting their characteristics, and elevating solubility and bioavailability. Furthermore, this study aims to enhance the chemical and physical stability of these compounds during extended periods of storage. Ultimately, this research endeavours to provide insights into the efficacy of self-nano-emulsion in enhancing solubility and bioavailability, thereby aiding researchers in comprehending its potential applications.