Abstract
Clay minerals are mainly used around traditional cosmetics and industrial products, but currently their target application is continuously expanding into pharmaceutical industry and tissue engineering. To broaden the knowledge of in vitro cytotoxicity of allophane nanoparticles against human cancer cells, the cytotoxicity of both natural and synthetic allophane nanoparticles for cultured human alveolar basal epithelial (A549) cells was examined. For both natural and synthetic allophones, the A549 cell viability was maintained at >70% for concentration up to 3160μg/mL, implying higher biocompatibility of allophane nanoparticles as compared with that of hectorite nanoparticles. The cell adhesion kinetics coupled with cytotoxic characteristics against A549 cells was analyzed using quartz crystal microbalance (QCM) technique to distinguish the dynamic cell adhesion signatures.
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