Abstract
Aconitum kusnezoffii used as an analgesic and anti-inflammatory. It is often used not only in Mongolian medicine but also in traditional Chinese medicine. However, there are few studies on its impact of inflammatory cytokines. This study explored the effects of Aconitum kusnezoffii in vitro used human colon cancer (Caco-2) cells. Cytotoxicity was assessed by measuring effects on expression of IL-1β, IL-6, IL-8, and TNF-α used enzyme-linked immunosorbent assay (ELISA). In vitro study demonstrated that incubation of Caco-2 cells with some kinds of Aconitum kusnezoffii at some concentrations inhibit secretion of TNF-α and FAXIU ACONITUM KUSNEZOFFII could inhibit the secretion of IL-1β. While IL-6 and IL-8 levels were unaffected after 24 h of treatment with Aconitum kusnezoffii, qujian Aconitum kusnezoffii, faxiu Aconitum kusnezoffii.
Highlights
Aconitum kusnezoffii grows in the forest edge meadow, valley meadow and broad-leaved forest
Cytotoxicity was assessed by measuring effects on expression of IL-1β, IL-6, IL-8, and tumor necrosis factor-α (TNF-α) used enzyme-linked immunosorbent assay (ELISA)
We investigated the change of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) from Caco-2 cells induced with raw Aconitum kusnezoffii, faxiu Aconitum Kusnezoffii, qujian Aconitum kusnezoffii to evaluate the medicinal value of Aconitum kusnezoffii and provide evidence for the development of more efficacy and clinical application of Aconitum kusnezoffii
Summary
Aconitum kusnezoffii grows in the forest edge meadow, valley meadow and broad-leaved forest. It is mainly produced in northern Inner Mongolia, Jilin and Heilongjiang provinces. We investigated the change of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) from Caco-2 cells induced with raw Aconitum kusnezoffii, faxiu Aconitum Kusnezoffii, qujian Aconitum kusnezoffii to evaluate the medicinal value of Aconitum kusnezoffii and provide evidence for the development of more efficacy and clinical application of Aconitum kusnezoffii. It will accumulate data for pharmacological action of Aconitum kusnezoffii and provide a scientific basis for the rational and safe use of the medicinal material, especially its use method
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