Abstract

Tunisian Juglans regia bark ethanol extract (JREE) was examined for antibacterial, antibiofilm, and antioxidant activity. Its anti-proliferative effect was evaluated on normal (MRC-5) and cancer (HT29 and HEp-2) cell lines. The data revealed that JREE inhibited the growth of pathogenic bacteria (MICs value ranged from 32 to 128 μg.mL-1) and induced a strong antibiofilm effect (BIC50 was 23, 30, and 43 μg.mL-1 for Micrococcus luteus, Staphylococcus epidermidis, and Staphylococcus aureus, respectively). The JREE showed high scavenging property against 2,2-diphenyl-l-1-picrylhydrazil (DPPH) radical (IC50 = 3.5 μg.mL-1) and exhibited anti-proliferative effects with IC50 values ranging from 6.6 to 25.5 μg.mL-1.

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