Cytotoxicity and Antioxidant Activity of Beta vulgaris Extract Released from Grafted Carbon Nanotubes Based Nanocomposites

Abstract

SummaryThis work deals with preparation and characterization of novel grafted multi‐walled carbon nanotubes (MWCNTs) with dodecenyl succinic anhydride (DSA) in presence of plant extract (Beta vulgaris) and hydroxyapatite nanoparticles (HA). Moreover, cytotoxicity and antioxidant activity of the prepared nanocomposites using Ehrlich ascites carcinoma cells (EACC) were examined and evaluated. The prepared nanocomposites were characterized using Fourier transform infrared spectroscopy (FTIR) and transmission electron microscope (TEM). In addition to the particle size and zeta potential were recorded. The grafting technique was significantly enhanced the nanotube dispersibility and long term stability in the aqueous solution. The results indicated that the conjugation between B. vulgaris extract, HA nanoparticles and functionalized MWCNTs exhibited great antioxidant activity through the scavenging of the free radicals using DPPH assay. Also, the encapsulated B. vulgaris extract within the grafted MWCNTs based nanocomposites exhibited acceptable effect on the viability of EACC in compared with the standard (Vincrestine®). In other words, these novel functionalized MWCNTs based nanocomposites could be used as antioxidant and antitumor agents in the future after further studies.