Synthesis and biological Evaluation of the toxicity of grafted 2-mercaptobenzoimidazole multi walled carbon nano tubes (MWCNTs)

Abstract

This work presents chemical functionalization of multi-walled carbon nano tubes (MWCNTs) through chemical modifications. Antibacterial conjugated MWCNTs were synthesized involving the sequential steps of carboxylation. Formation of the active intermediates using Hydroxy benzo triazole (HOBt) was done in order to achieve conjugated 2-mercapto benzo imidazole (MWCNT-h) as the final compound. The modification of MWCNTs with antibacterial drug was checked by Fourier transform-infrared spectroscopy, Raman spectroscopy and Thermo gravimetric analysis. Size and surface characteristics of chemically modified MWCNTs were monitored by scanning electron microscopy and Atomic Force Microscope (AFM). Minimal Inhibitory Concentration (MIC) and Antimicrobial activity of functionalized and carboxyl MWCNTs was studied on two Gram-negative bacteria as well as one Gram positive bacteria. The MIC results show that functionalized MWCNTs with anti-bacterial drugs have more effective results than bare drug and carboxyl MWCNTs individually against all studied bacteria.