Abstract
In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (1–10) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed.
Highlights
Several species of Hedychium are used widely in traditional medicines for treatment of skin diseases, stomach ailments, cough and apoplexy, and as an analgesic, anti-inflammatory, antimicrobial and anti-rheumatic treatment [1,2]
Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed
Previous phytochemical studies on Hedychium species revealed the presence of diarylheptanoids, sesquiterpenes and diterpenes, some of which showed hepatoprotective effects [3], antiinflammatory activities [4] and cytotoxicity against various cancer cells [5,6,7,8,9,10,11,12]
Summary
Several species of Hedychium are used widely in traditional medicines for treatment of skin diseases, stomach ailments, cough and apoplexy, and as an analgesic, anti-inflammatory, antimicrobial and anti-rheumatic treatment [1,2]. No detailed phytochemical and pharmacological investigation on H. ellipticum has been reported, except for a report on the chemical composition of leave and rhizome essential oils, which showed that (E)- nerolidol and 1,8-cineole were the major constituents [13,14]. In our preliminary investigation on the bioactivities of Hedychium plants, we found that the crude n-hexane and CH2 Cl2 extracts of H. ellipticum rhizomes showed moderated antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against human cancer cell lines. The aim of the present work is to determine the chemical constituents from the rhizomes of H. ellipticum and to evaluate their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The structure–activity relationships of all isolated compounds were reported
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