Abstract
Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung cancer), KB (oral human epidermal carcinoma) and MCF-7 (breast cancer) cancer cell lines. All limonoids (1-5) showed inhibitory effect against Plasmodium falciparum with IC(50) values ranging from 2.06 to 6.31 microg/ml. Only azadiradione (2) exhibited strong inhibitory effect against Mycobacterium tuberculosis with the MIC of 6.25 microg/ml. Compounds 1-4 also showed cytotoxic activity against NCI-H187, KB and MCF-7 cancer cell lines and dysobinine (1) had the highest activity with IC(50) of 1.67, 3.17 and 2.15 microg/ml, respectively.
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