Abstract
It is reported that oligosaccharides have antitumoric effects on cancer cells. To evaluate the in vivo antitumor potentials of oligosaccharides, we obtained substance A from them. In this study, we treated three kinds of cell lines(Hep3B, A549, 293T) with substance A in concentration of 2%, 1%, 0.5% respectively and incubated them 24 hours. Then we used MTT assay to measure viability of cells. As a result, the viability of A549 cells decreased as the concentration of substance A became higher while other cells(Hep3B, 293T) were almost same. Survival rates of A549 cells were 84%, 82% and 68% when treated with substance A in concentration of 0.5%, 1% and 2% respectively. In all concentrations, cytotoxic effects of substance A on A549 cells were about 5 times stronger than on 293T cells. Our results suggested that substance A has selective cytotoxic effects on A549 cell lines. This study demonstrated that substance A has antitumor effects on human lung cancer.
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