Abstract
The study was conducted to evaluate antitumor effects of green tea (Camellia sinensis) extracts (aqueous and methanolic) on Rhabdomyosarcoma; cell line and a normal cell line; mouse embryo fibroblast; Chemical detections of green tea extracts revealed that the aqueous and methanolic extracts were positive for flavonoids, alkaloids, phenol and glycosides. The percentage growth inhibition of five plant concentrations (50, 100, 250, 500 and 1000 µg/ml) were assessed in vitro using tumor cell lines Rhabdomyosarcoma and normal cell line mouse embryonic fibroblasts. The results revealed that the five concentrations of the plant extracts showed anti-tumor properties in a concentration-dependent manner, and the methanolic extract recorded better values of percentage growth inhibition than the aqueous extract in Rhabdomyosarcoma cell lines, while, less percentage growth inhibition values were recorded in the mouse embryo fibroblast cell line.
Highlights
(aqueous and methanolic) on Rhabdomyosarcoma; cell line and a normal cell line; mouse embryo fibroblast; Chemical detections of green tea extracts revealed that the aqueous and methanolic extracts were positive for flavonoids, alkaloids, phenol and glycosides
The phytochemical screening of green tea revealed the presence of alkaloids, flavonoids, phenols and glycosides (Table, 1)
The amount of catechin in various tea extract was in the order green tea (26.7%), oolong tea (23.2%), pouching tea (15.8%) and black tea (14.3%) (3 and 4) The Results revealed that the 5th concentration (1000 mg/ml) of the aqueous and methanolic extract was recorded the highest percentage growth inhibition in Rhabdomyosarcoma cell lines (87 and 90) % respectively
Summary
(aqueous and methanolic) on Rhabdomyosarcoma; cell line and a normal cell line; mouse embryo fibroblast; Chemical detections of green tea extracts revealed that the aqueous and methanolic extracts were positive for flavonoids, alkaloids, phenol and glycosides. Is green tea catechins which comprise four this study was conducted to evaluate major epicatechin derivatives; namely, antitumor effects of green tea (Camellia epicatechin (EC), epigallocatechin, (EGC), sinensis) extracts (aqueous and methanolic) on epicatechingallate (ECG), and tumor cell line and a normal cell line.
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