Abstract
• Three undescribed triterpenoids with rare skeletons ( 1 - 3 ) were reported. • One unreported gypenoside ( 4 ) was isolated. • The absolute configurations were determined by ECD analysis. • Their antiproliferative effects were evaluated in a variety of cell lines. Three undescribed dammarane-type triterpenoids with rare carbon skeletons ( 1 - 3 ), together with one unreported gypenoside ( 4 ), were isolated from a acid hydrolysis product of Gynostemma pentaphyllum (Thunb.) Makino. Their molecular structures were elucidated via a combination of spectroscopic and spectrometric data, while the absolute configurations of compounds 1 , 2 and 4 were determined by electronic circular dichroism (ECD) analyse. Notably, compounds 1 - 3 possess a 19(10→1)abeo structural moiety in the A ring. Saponin 4 possesses an unusual cyclopentenone side chain. Compounds 1 , 2 and 4 were screened for their antiproliferative effects against HepG2, MCF-7 and DU145 cell lines.
Published Version
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