Abstract
The terpenoidal oxaliplatin derivatives ( 6) and ( 12) were newly synthesized using 2β,3α-dihydroxy-11-oxo-18β-olean-12-ene-30-oic acid ( 1) and 2α,2β-dihydroxy-18β-ursan-12-ene-28-oic acid ( 7) as starting materials. The synthesized compounds were evaluated for their cytotoxicity and antioxidant activities and were compared to Oxaliplatin ® and vitamin C as positive controls. Some of the compounds exhibited better cytotoxicity and antioxidant activities than the reference controls. The detailed synthesis, spectroscopic data, toxicity (LD 50) and pharmacological screening for the synthesized compounds were reported.
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