Abstract
Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I. wightii, showed significant cytotoxicity against lung cancer and neuroblastoma cell lines with IC50 values of 6 and 4.2 µg mL−1, respectively. The prevention of deoxyribose degradation activity of melissoidesin was significant and the IC50 value was calculated to be 163.1 µg mL−1. The anticarcinogenic activity of melissoidesin by comet assay showed significant DNA damage protecting activity in a dose-dependent manner.
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