Abstract
In this paper, we report the synthesis, characterization and antitumor studies of Co(II), Ni(II) and Cu(II) complexes with two potentially hexadentate ligands. Antitumor activity of the prepared ligands and its complexes against human breast cancer cell line MCF-7 was determined. The level of total protein, nucleic acids (RNA and DNA) and nitric oxide (NO) in MCF-7 treated cells was estimated. Antitumor activities of the complexes are accompanied with over-production of free and superoxide radicals allowed reactive oxygen species-mediated tumor cell death. The results show significant antitumor activity comparable to cisplatin
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
