Abstract
Fatal encephalitis developed in newborn Swiss mice following intracerebral inoculation with Nariva virus. By light microscopic examination Nariva virus encephalitis is characterized by a discreete astrogliosis, lymphocytic perivascular infiltrations and diffused microglial proliferation which occurred in form of nodules. Electron microscopic examination of infected mouse brain tissues revealed marked morphological damage to the neurons and the astroglial cells and an increased distention of the extracellular spaces. In conjunction with the cytopathic changes synthesis of viral components,i. e. tubular structures, were observed in infected neuron and astroglial cells only in the cytoplasm. The oligodendroglia and microglial cells showed no morphological alterations or viral inclusion bodies. Tubular structures of 18–20 mμ in diameter indistinguishable from nucleocapsids of larger paramyxoviruses, were observed. Other alteration included proliferation of “intralysosomal nucleocapsids” which seems to be an important consequence of Nariva virus infection. Virus particles are pleomorphic and have an average diameter of 200 mμ.
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