Abstract
Young rats were given two doses of 50 mg 5-fluorouracil with a 22-hour interval. One hour after the second dose they were given either cytidine-3H or leucine-3H and killed three hours later. Radioautographs of the livers revealed a decrease in RNA labelling, whereas the protein labelling was essentially uninfluenced. The liver cells exhibited an increase in nucleolar volume. Electron microscopy revealed changes in the ultrastructure of the liver cell nucleoli, while other parts of the cells were essentially unaltered.
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