Abstract
In this paper, a new formulation of nasal spray was set up based on the extract of lemon pulp, obtained by using a new solid-liquid technology of extraction, added to pure Aloe juice, soluble propoli, and essential oils of Ravensara and Niaouly. It was tested in a clinical study in which 100 subjects were recruited for a period of one month. Nasal scraping was used for collecting samples and after the application of the May-Grünwald Giemsa standard technique, glass slides were analysed by using optical microscope with a 1000x oil immersion. A control group constituted of ten people was recruited as control and this group was administered with physiological solution (saline solution). The comparison of results obtained before and after the application of nasal spray showed a total reduction of eosinophils granulocytes and mast cells; clinical data were confirmed by improvement of clinical pictures of patients. The lemon-based nasal spray was a good alternative to conventional medicine for the treatment of perennial and seasonal allergic and vasomotor rhinopathy.
Highlights
A new formulation of nasal spray was set up based on the extract of lemon pulp, obtained by using a new solid-liquid technology of extraction, added to pure Aloe juice, soluble propoli, and essential oils of Ravensara and Niaouly
The comparison of results obtained before and after the application of nasal spray showed a total reduction of eosinophils granulocytes and mast cells; clinical data were confirmed by improvement of clinical pictures of patients
Nasal cytology is of remarkable importance in the study of rhinosinus diseases, especially the vasomotor rhinitis (VMR), as it represents valuable means of differential diagnosis between allergic/nonallergic diseases and bacterial/viral infections
Summary
A new formulation of nasal spray was set up based on the extract of lemon pulp, obtained by using a new solid-liquid technology of extraction, added to pure Aloe juice, soluble propoli, and essential oils of Ravensara and Niaouly It was tested in a clinical study in which 100 subjects were recruited for a period of one month. Nasal cytology is of remarkable importance in the study of rhinosinus diseases, especially the vasomotor rhinitis (VMR), as it represents valuable means of differential diagnosis between allergic/nonallergic diseases and bacterial/viral infections It is a popular and proven method, considering that it dates back to 1889, when Gollash [1] identified the numerous eosinophils in the nasal secretion from an asthmatic patient and attributed their presence a key role in the pathogenesis of asthma. The lemon extract has been prepared using an innovative solid-liquid extraction method, the Extractor Naviglio or Dynamic Fast Solid-Liquid Extractor [8]; this device features an innovative solid-liquid extraction technique that allows solid matrices, containing substances that can be extracted in organic or inorganic solvent and mixtures thereof, to be quickly extracted [9]
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