Abstract
SUMMARYPederin (10 −4M and 2.10−4″M), acting on the cleaving eggs of Triturus helveticus Raz., does not prevent or arrest cleavage before mitosis. It dissociates the achromatic apparatus from the nuclei, inducing achromosomic mitoses, but does not destroy either the spindle or the asters. Disfunction of kinetochores results in aberrant polar chromosomes not being included in the equatorial plate (so-called three groups metaphase) and aberrant caryomeres.The nuclei are enlarged, their evolution is slowed down or stopped; different types of nuclei are described and their signification discussed. Enlargement of nuclei is believed to be related to a prolonged incorporation of cytoplasmic proteins during telo-prophase. Chromosome breakage may occur, but appears as secondary to agglutination.The cytological action of pederin is fundamentally different from that of alkylating agents, of amikhellin, of quinolin, and naturally of colchicine.
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