Abstract
T helper type 1(Th1)cytokines predominate in primary syphilis, while Th2 cytokines predominate in secondary syphilis. Th1 cytokines such as interleukin(IL)-2 and interferon(IFN)-γ can enhance the ability of T cells to promote the clearance of Treponema pallidum(TP)and healing of skin lesions. Along with the progression of syphilis, Th1 cytokines decrease, while Th2 cytokines(including IL-4 and IL-10)increase to inhibit cellular immunity and result in long-term latency of TP infection in the body. Th7 cells can secrete IL-7 and exert a protective role in anti-syphilis immunity. Other kinds of cytokines including IFN and IL-12 also play important roles in anti-syphilis immune response. Key words: Syphilis; Cytokines; Immunology
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