Abstract
Engraftment after bone marrow transplantation (BMT) can be monitored with genetic markers. Cytogenetic markers are the ones that can be studied earliest. Of 27 patients studied, 16 had a sex-mismatched donor, and in 8 cases, there were discriminative markers identified with regular Giemsa and Q-banding. In one case, there was a rather slight polymorphism of the C-bands of chromosomes #9. Thus, donors' cells were identifiable in 25 of 27 cases (93%). The markers studied easiest are the sex chromosomes in sex-mismatched BMT. Different fluorescence of the centromeric regions of chromosomes #3 and characteristic satellites of acrocentric chromosomes are rather frequent and also well suited to discriminate donors' from patients' cells. Nonprominent variabilities (fluorescence of the centromeric regions of chromosomes #4 and #6 after Q-banding), rare polymorphisms (pericentric inversions of chromosomes #1 and #9), and difficult to evaluate polymorphisms (heterochromatic regions of chromosomes #1, #9, and #16) are not very practical for the routine monitoring of engraftment after BMT.
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