Abstract
Background & Objective:Spontaneous pregnancy loss has always been the frustrating experience for the couples and concern clinician. Chromosomal abnormality in either of the parent is considered to be the one of the leading cause of recurrent spontaneous miscarriages. This study was designed to evaluate the possible chromosomal etiology of miscarriage and the subsequent intimacy of maternal or paternal genetic abnormality.Methods:This case-control study was conducted between January 2016 and October 2016 at a tertiary care hospital in Karachi. A total of thirty-two couples were selected who had suffered with recurrent spontaneous miscarriages (RSM). Using conventional cytogenetic technique karyotyping was performed on all of the subjects. For the control twenty couples were also selected with no history of pregnancy loss. All the karyotypes were recorded on the standard method. Data was analyzed through SPSS version 22.Results:Among thirty-two cases nine cases were found to have abnormal karyotype. In which sex chromosomal trisomy=02 (46,XY/47,XXY), marker chromosome=01 (47,XX,+mar), Robertsonian translocation=01 (45,XY,der,(14:21),(q10;q10)), reciprocal translocation=01 (46,XX,t(11;22)(q23;q11.2)), inversion=02 (46,XX,inv(9)(p11q13)) and minor structural abnormalities=02 (46,XX,15PS+) were found. Approximately equal ratio with 1:1.25 was observed among male and female carrier respectively. Non-significant difference was found between the ages of both carriers (p=0.34). Though a significant different value was calculated in the case of number of miscarriage (p=0.004*). Moreover, no significant association was found among spontaneous miscarriage (SM) and recurrent spontaneous miscarriage (RSM) with respect to maternal age (p= 0.157).Conclusion:In the recent study possible chromosomal abnormalities suggested the evaluation of the patient with the history of recurrent spontaneous miscarriage must include conventional cytogenetic. Moreover, probe development and extended investigation can ease the prognosis among pregnancy related complication.
Highlights
Pregnancy loss is always destructive for the couple and their clinician
In subject group of 32 couples were recruited with the history of recurrent spontaneous miscarriages, and 20 healthy couples were included as the control group
Conventional cytogenetic analysis was carried out, and numerical and structural abnormalities were detected among nine cases (28.12%)
Summary
Pregnancy loss is always destructive for the couple and their clinician. Spontaneous miscarriage (SM) is the most common dilemma of the reproductive event without any prior history or reason, comes about 1-3% of all women of reproductive age. Spontaneous miscarriage is nature’s quality control for selecting genetically normal offspring. Though, it is always devastating for the couple who suffers with miscarriage. Chromosomal abnormality in either of the parent is considered to be the one of the leading cause of recurrent spontaneous miscarriages. This study was designed to evaluate the possible chromosomal etiology of miscarriage and the subsequent intimacy of maternal or paternal genetic abnormality. A total of thirty-two couples were selected who had suffered with recurrent spontaneous miscarriages (RSM). For the control twenty couples were selected with no history of pregnancy loss. Conclusion: In the recent study possible chromosomal abnormalities suggested the evaluation of the patient with the history of recurrent spontaneous miscarriage must include conventional cytogenetic. Probe development and extended investigation can ease the prognosis among pregnancy related complication
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