Abstract
Three thiocarbamate herbicides, butylate ( S-ethyl-diisobutylthiocarbamate), vernolate ( S-propyl dipropylthiocarbamate) and molinate ( S-ethyl- N, N-hexamethylenethiocarbamate) were assayed for cytogenetic effect in the mouse bone marrow micronucleus test. Butylate was inactive in bone marrow, vernolate caused a marginal increase in the incidence of micronucleated polychromatic erythrocytes only at a high toxic dose level. Molinate, the N, N-hexamethylene derivative was, however, strongly active in the bone marrow, causing a high frequency of micronucleated erythrocytes, even at subtoxic concentrations.
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