Cytogenetic characteristics of T-lymphoid cell strains ofPapio hamadryas

Abstract

A detailed cytogenetic study of three T-lymphoid strains ofPapio hamadryas cells was carried out. Two strains, LNPH-5(T) and SPH-7(T), had normal karyotype 42,XX at the 43rd and 56th passages. After long culturing the initial SPH-7(T) cells were completely replaced by the 87th passage by cells with a pseudodiploid karyotype 42,XX,der(1), der(2), der(13), der(14), der(X). SPH-8(T) strain (36th passage) contained two cell clones, with predominant normal (42,XY) and pseudodiploid 42,XY, der(7)t(7;X) (qter;pter), del(13)(q21),del(14)(q16) karyotype. The patterns of karyotypic variability of simian and human T-lymphoid cell strains are similar.