Abstract
Human fibroblast cell strains differ markedly in their susceptibility to SV40 transformation. The strains so far tested fall into three classes—susceptible, normal, and resistant. In most cases susceptible strains have been obtained from persons with genetic diseases associated with a high risk of neoplasia. The present studies show that the transformation frequency is directly related to the fraction of SV40 T antigen-producing cells seen in the acute infection. In susceptible strains the efficiency of SV40 T antigen induction per plaque-forming unit is 1 in 250; in resistant strains the efficiency is 1 in 10 5. Once having formed T antigen, however, the cells of each strain have a comparable probability (1 in 250) of giving rise to transformed colonies. The difference in transformation susceptibility among human cell strains thus involves a step prior to or associated with SV40 T antigen induction.
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