Abstract
Nano-sintered Ti-15Zr-4Nb-2Ta-0.2Pd alloy made up of non-toxic elements was produced by mechanical alloying using high energy ball mill and synthesized by spark plasma sintering (SPS) hot furnace with an objective to develop cytocompatible metallic implant. These were done to develop an alloy capable of avoiding adverse body reaction and increase the longevity of human life by replacing the lost or diseased organs to restore form and function. Microstructure obtained shows well defined grain boundary lines for sintered CP Ti with no surface porosity. Sintered Ti-6Al-4V microstructure showed well defined sinter-bonding of grain matrix with white rings on grain boundary lines and sintered Ti-15Zr-4Nb-2Ta-0.2Pd alloy showed no definite orientation of grains on the surface and had obvious visible grain boundary lines with a few observable surface pores across the area of the specimen. Cytocompatibility test was conducted by culturing CP Ti, Ti-6Al-4V and Ti-15Zr-4Nb2Ta-0.2Pd alloys separately with murine fibroblast L929 at a concentration of 70 cells/well, and incubated for 7 days at a temperature of 37 °C. Amongst CP Ti, Ti-6Al-4V and Ti-15Zr-4Nb-2Ta-0.2Pd specimen surfaces, the murine fibroblast L929 cells were well attached, grew and formed more colonies on CP Ti and Ti-15Zr-4Nb-2Ta-0.2Pd and least attached to the Ti-6Al-4V surface.
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