Cytochrome P4501A1 genetic polymorphisms breast cancer risk

Abstract

The CYP1A1 gene is highly polymorphic in human populations and ethnic differences in the distribution of these polymorphisms have been reported in various populations. Aims: The aim of the study to evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer susceptibility in Sudanese women. Methods: 100 patients and 100 controls were studied after written consent. A questionnaire extracted sociodemographic data, family history of breast cancer and gynecological history. Clinical examination was performed including weight and heights. Blood was drawn for PCR and RFLP analysis for CYP1A1 genotyping. Results: Premenopausal age and later age at menopause, education levels, family history of breast cancer and BMI had significant associations with breast cancer risk in Sudanese women. The CYP1A1 M1 genotype was not associated with the risk of breast cancer in Premenopausal and postmenopausal ages neither were the CYP1A1 M3 genotypes in this respect. There were no homozygous CYP1A1 M1 (C/C) and the CYP1A1 M3 (C/C) genotypes in our study subjects. The homozygous CYP1A1 M2 (A/A) genotype had a significant association with risk reduction of breast cancer in premenopausal women. The heterozygous CYP1A1 M2 (A/G) and the homozygous (G/G) were associated with a significant increased risk of breast cancer. Conclusion: This study has shown that the CYP1A1 M2 polymorphism has an association with the risk of developing breast cancer among Sudanese patients.