Abstract
Neonatal hyperbilirubinemia results from a readiness for the bilirubin production in neonates and limited their ability to excrete it. The diagnosis of hyperbilirubinemia based on yellow discoloration of the skin and whiteness of eyes, idle in the child's movement and the lack of lactation. The baby seems sick or is difficult to awaken. Serum cystatin-C, is a low molecular protein that belongs to the family of cysteine protease inhibitor, was proposed as an endogenous filtration marker. In this study sixty neonatal patients suffering from hyperbilirubinemia (35 males,25female) were collected from prematurity unit (PU) in Al-Zahra Educational Hospital/Al-Najaf Al-Ashraf during the period from August,2020 to February,2021. A group of 20 randomly (12male, 8female) selected apparently healthy group. After diagnosis of hyperbilirubinemia, the patients were divided into three groups according to age (1-3), (4-7) and (7-9) days. The result reveals that significant increase (p<0.05) in serum cystatin-C in neonatal hyperbilirubinemia as compared with healthy group. The result of study reveals no significant increase(p<0.05) in serum levels of cystatin-C, while the study shows a significant increase (p<0.05) between male and female in serum levels of bilirubin.
Highlights
Neonatal jaundice It is the common condition of medical importance in newborns, calledNeonatal jaundice or Neonatal icterus, in which the yellow pigment bilirubin can accumulate in the extracellular fluids by the way in the skin, over the sclera in the membranes of conjunctival and in other membranes of mucous after birth within the first few days, as well as skin prevails in yellow almost in face and extending down onto the chest, jaundice of neonate in normal circumstances is harmless: this condition is often seen in infants around the second day after birth, and goes on till day 8 in normal births, or to about day 14 in premature births
Cystatin-C used as an alternative biomarker technique, and performed by Automated to evaluation of kidney function is linked with microtiter plate ELISA reader
MATERIALS AND METHODS Samples The study was conducted on sixty neonates hyperbilirubinemia patients (25female, 35male), suffering from severe jaundice (TSB≥15mg/dl).The patient's age was ranging from 1 to 9 days The study was carried out from August, 2020 to February, 2021, samples were collected from the prematurity unit(PU)in Al-Zahra Educational Hospital/AlNajaf Al-Ashraf
Summary
Neonatal jaundice It is the common condition of medical importance in newborns, called. 2000; Maria et al.,2008), formerly post-gamma- comparison between the patients and healthy globulin, gamma trace or polypeptide of groups were tested by one-way ANOVA test, neuroendocrine basic (Filler et al.,2004). It is non glycated protein contains about 122 amino acids, it is a member of cystein proteinase inhibitors family (Christine et al.,2010). It is the house keeping product of gene in all nucleated analyzed by t-test. This protein discovered for the first time of healthy patients in the cerebrospinal fluid,
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