Abstract
This study aimed to explore whether the polymorphisms of CYP4F2 and CYP3A5 are correlated with the risk of lung cancer development. A case–control study was conducted among 510 patients with pathologically confirmed lung cancer as the case group and 504 healthy individuals as the control group. Four single-nucleotide polymorphisms of the CYP4F2 and CYP3A5 genes were genotyped, and their correlations with the risk of lung cancer were examined using Chi-square test and logistic regression analysis. Stratified analysis found that the rs3093105 and rs3093106 loci of CYP4F2 gene were significantly associated with lower risk of lung cancer (P = 0.012, OR 0.64, 95% CI 0.45–0.91). The correlation was related to patients’ age and sex and pathological type of lung cancer. Similarly, the rs10242455 loci of CYP3A5 gene showed a statistical significance between the case group and the control group (P = 0.018, OR 0.71, 95% CI 0.53–0.94), which also was associated with reduced risk of squamous cell lung cancer in the dominant and additive models (dominant: OR 0.66, 95% CI 0.46–0.94, P = 0.021; additive: OR 0.71, 95% CI 0.53–0.95, P = 0.023). CYP4F2 and CYP3A5 gene polymorphisms are associated with the reduced risk of non-small cell lung cancer, and its correlation is related to patients’ age and sex and pathological type of lung cancer.
Highlights
Lung cancer is one of the most common malignant tumors [1]
A recent study shows that the expression of CYP4F2 is closely related to hepatocellular carcinoma cells, which may contribute to tumor progression [10]
Our study has been the first to report that there is a significant correlation between CYP4F2 gene polymorphisms and lung cancer in Chinese Han population, and this is associated with lowered risk of lung cancer in people older than 58 years old, lung adenocarcinoma and men
Summary
Lung cancer is one of the most common malignant tumors [1]. With the increase in detection rate of lung cancer and the aggravation of environmental pollution, morbidity and mortality of lung cancer are increasing year by year [2]. Clinical and Experimental Medicine (2020) 20:461–468 of carcinogens and anticancer drugs [10, 11] These reactive metabolites would interact with DNA, thereby causing altered gene expression or function, and eventually carcinogenesis [12]. A recent study shows that the expression of CYP4F2 is closely related to hepatocellular carcinoma cells, which may contribute to tumor progression [10]. Relative studies demonstrate that 20-HETE (CYP4F2related products) was associated with the growth of tumors in mouse non-small cell lung cancer cell lines [13]. Another study confirmed that CYP3A5 was associated with lung cancer in the population of Taiwan, China [14]. Little research has been done about the association between CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in the Chinese Han population of mainland China
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