Abstract
Epidemiological evidence remains conflicting regarding diet and risk of lung cancer. We sought to systematically investigate whether dietary factors are associated with the risk of incident lung cancer in the UK Biobank. A total of 416,588 participants (54% women) from the UK Biobank were included in the present study. Based on baseline data from FFQs, 3 main dietary patterns were identified by using principal component analysis. Cox proportional hazards models were used to investigate the association of individual food groups and dietary patterns with lung cancer risk. During a median follow-up of 7.13 y, 1782 incident lung cancer cases were documented. The association analysis showed high intake of red meat and processed meat was associated with an increased risk of lung cancer (HRper 50g/d: 1.36; 95% CI: 1.13, 1.65 for red meat; HRper 25g/d: 1.30; 95% CI: 1.10, 1.53 for processed meat). However, the consumption of fruits (HRper 100g/d: 0.90; 95% CI: 0.84, 0.95), vegetables (HRper 100g/d: 0.89; 95% CI: 0.81, 0.99), breakfast cereals (HRper 50g/d: 0.81; 95% CI: 0.74, 0.89), and dietary fiber (HRper 5g/d: 0.76; 95% CI: 0.69, 0.84) was inversely associated with the risk of lung cancer. For the dietary pattern analysis [quartile (Q) comparison], high adherence to the Prudent pattern (HRQ4 compared with Q1: 0.84; 95% CI: 0.73, 0.96) was associated with a lower risk of lung cancer, whereas the Western pattern (HRQ4 compared with Q1: 1.27; 95% CI: 1.11, 1.46) was associated with a higher risk of lung cancer. Our study indicated that a diet characterized by high intake of fruits, vegetables, breakfast cereals, and dietary fiber, as well as low intake of red meat and processed meat, was associated with a lower risk of lung cancer.
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