Abstract
BackgroundCytochrome P4502D6 (CYP2D6) enzyme is involved in the metabolism pathway of many chemical carcinogenesis. Polymorphisms of CYP2D6 gene have been associated with altered risk of breast cancer, besides the response to anti-cancer drugs. Therefore, this study aims to assess the association of CYP2D6*3 (A2549del), CYP2D6*4 (G1934A) and CYP2D6*10 (C100T) Polymorphisms with breast cancer risk in Moroccan population. It also aims to evaluate association between various tumor characteristics and CYP2D6 variants. MethodsWe performed a case-control study within 200 breast cancer patients and 200 sex and age-matched healthy controls. A polymerase chain reaction-restriction fragment-length polymorphism analysis was used for genotyping. Then, statistical analysis was performed to evaluate allelic and genotypic frequencies, as well as genetic variation between cases and controls and tumor characteristics. ResultsThe CYP2D6*3 (A/del) genotype was significantly associated with breast cancer risk in Moroccan patients (P = 0.003). Furthermore, carriers of CYP2D6*3 delA allele seem to be at high risk of developing breast cancer (P = 0.005). Haplotype analysis showed that the haplotype containing CYP2D6*3 allele (delA) increase significantly susceptibility of breast cancer. While no risk variation was found in CYP2D6*4 and CYP2D6*10 variants. ConclusionOur results showed association between CYP2D6*3 and increased risk of breast cancer among Moroccan patients. However, further studies with larger samples are required to support this finding.
Published Version
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