CYP2C9, CYP4F2, VKORC1 Gene Polymorphism in Buryat Population

Abstract

The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age of 57.51 ± 10.88 years. Genetic typing of DNA samples was performed by polymerase chain reaction (RT-PCR). The frequency of the minor alleles *2 and *3 of the CYP2C9 gene was 2.03 and 3.05%, respectively. The frequency of the allele T of the CYP4F2 gene was 31.22%; the frequency of the allele A of the VKORC1 gene was 85.28%. The obtained results could be used in the prognosis of pharmacotherapy of warfarin in the population Buryat population.