Abstract
Therapeutic monitoring of cyclosporine has been a controversial area. The unique physiological and pharmacological properties of cyclosporine are partly responsible for the inconsistent correlation between blood concentrations and clinical effect. The variety of analytical methods has also contributed to conflicting opinions. Recently, a number of selective methods for cyclosporine in whole blood have become available, which should help produce consistent results between laboratories. The value of therapeutic monitoring appears to be decreasing the incidence of nephrotoxicity and identifying noncompliance.
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