Cycloplegic Effect of 1% Atropine Compared to 1% Cyclopentolate − 1% Tropicamide Combination in Children

Abstract

Objective: To compare the cycloplegic effect of 1% Atropine to 1% cyclopentolate plus 1%Tropicamide (CT) combination in children. Methods: This was a cross-over interventional study among children aged 0–15 years in our eye clinic in year 2017. The children were selected using a stratified sampling method. Each child had a non-cycloplegic refraction then refraction after instillation of a drop of 1% Cyclopentolate and 1% Tropicamide 5 minutes apart in the left eye.Parents were given 1% Atropine drops to be instilled twice daily for three days in the same eye before the return visit 3 weeks after and refraction was repeated. Results: The children were aged between 4 months and 15years with a higher number of females (60.7%). The difference between the mean of the spherical equivalent of non-cycloplegic refraction and that for CT combination was statistically significant (P