Abstract
The presence of cyclopiazonic acid (CPA) as a mycotoxin has been reported in feed and foodstuffs. The aim of this investigation was to determine the effects of CPA on reproductive functions of male mice. In this experiment, 40 mature male mice were randomly assigned into five groups (n=8): control, control-sham, CPA (0.03 mg/kg, body weight (BW)), CPA (0.06 mg/kg, BW) and CPA (0.12 mg/kg, BW). Following 28 days exposure to CPA, sperm quality parameters,in vitro fertilisation (IVF) capacity of sperms, serum testosterone level, Leydig cells number and serum total antioxidant capacity (TAC) were analysed. The results revealed a significant (P<0.05) reduction in sperm count, sperm viability, sperm motility, chromatin quality of sperm, sperms with intact DNA, IVF rate, testosterone level, Leydig cell distribution and TAC in comparison to the control group. The most prominent detrimental effects of CPA were found at the highest given dose level. Our results suggest that CPA at higher dose levels exerts detrimental effects on the male reproductive system. Moreover, these descriptive warrant further investigations into the specific mechanisms of action and the effects of CPA on spermatogenesis.
Published Version
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