Abstract
Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides mostly composed of six, seven, or eight α-D-glucopyranose units with α-1,4-glycosidic bonds to form toroidal structures. The CDs possess a hydrophilic exterior and hydrophobic interior with the ability to form an inclusion complex, especially with hydrophobic molecules. However, most existing studies are about conjugation CDs with peptide/protein focusing on the formation of new systems. The CD-peptide/protein can possess new abilities; particularly, the cavity can be applied in modulation properties of more complexed proteins. Most studies are focused on drug delivery, such as targeted delivery in cell-penetrating peptides or co-delivery. The co-delivery is based mostly on polylysine systems; on the other hand, the CD-peptide allows us to understand biomolecular mechanisms such as fibryllation or stem cell behaviour. Moreover, the CD-proteins are more complexed systems with a focus on targeted therapy; these conjugates might be controllable with various properties due to changes in their stability. Finally, the studies of CD-peptide/protein are promising in biomedical application and provide new possibilities for the conjugation of simple molecules to biomolecules.
Highlights
Faculty of Mathematics and Natural Science, Jan Dlugosz University in Czestochowa, Abstract: Cyclodextrins (CDs) are a family of macrocyclic oligosaccharides mostly composed of six, seven, or eight α-D-glucopyranose units with α-1,4-glycosidic bonds to form toroidal structures
The strategy focused on amide bond formation between the carboxyl and the amine group; CD and peptide consisted of both groups
The research showed the interesting application of CDpolylysine conjugate as a novel co-delivery system in gene delivery
Summary
Cyclodextrins (CDs) (Figure 1) are a family of macrocyclic oligosaccharides mostly composed of six, seven, or eight α-D-glucopyranose units, called α-CD, β-CD, and γ-CD. There are a significant amount of different molecules conjugated to the CDs, including peptides/proteins, nucleotides/nucleic acids [15], carbohydrates [16], steroids [17], and low molecular weight drugs [18]. The peptide/protein conjugation belongs to one of the most popular groups owing to the ability to modulate their properties. The addition of CDs to the complexed structure of protein can involve many new abilities n= 6, which. CD-peptide is focused on synthesis andstructural only structural ids [15], carbohydrates [16], steroids [17], and low molecular weight drugs [18]. Of protein can involve many new abilities which are induced mostly by inclusion complex with other low or high-molecular weight particles [14]. This review considered recent synthesis, physicochemical and biochemical properties, and applications of CD-peptide/protein conjugates
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