Cyclodextrin mediated controlled release of edaravone from pH-responsive sodium alginate and chitosan based nanocomposites

Abstract

The objective of the study is to enhance the aqueous solubility and stability of edaravone, a free radical scavenger drug. Inclusion complexes of edaravone with β-cyclodextrin were prepared by microwave irradiation and physical mixture method and confirmation of inclusion complexes were investigated by different analytical techniques such as FT-IR, ROESY, DSC, and 1H NMR. pH-sensitive nanocomposites based on chitosan (CH), sodium alginate (ALG), and bentonite (BN) were synthesized. To get the maximum percentage swelling different reaction parameters that are responsible for the synthesis of the nanocomposite were optimized and characterized by various techniques such as FESEM, EDS, XRD, and FT-IR. To regulate the drug delivery, inclusion complexes were directly loaded into the CH/ALG hydrogel, and CH/ALG/BN nanocomposite and release studies were evaluated at different pH environments. The solubility of edaravone was investigated by phase solubility and the graph results in a typical AL type behavior, suggesting the formation of a 1:1 stoichiometry inclusion complex. The comparative evaluation of drug release was explored by kinetic models. Controlled release of drug was achieved from CH/ALG/BN nanocomposite in comparison to CH/ALG hydrogel. The exploratory kinetic investigation revealed that β-CD plays a critical role in the drug release process by influencing polymer relaxation, resulting in slow release.