Abstract
Abstract This study aimed to investigate the effects of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides (CPP) on the glucose-lipid metabolism in T2DM rats. T2DM model was established in 40 Wistar rats which were then randomly divided into model, CPP-1, CPP-2 and CPP-3 groups. Ten normal rats were selected as the control group. The CPP-1, CPP-2 and CPP-3 group were intragastrically administrated with 100, 200 and 400 mg/kg CPP for 4 weeks, respectively. Results showed that, during the treatment, compared with model group, in CPP treatment groups the T2DM symptoms were lightened, and the body weight was improved. After treatment, compared with model group, in CPP-3 group the blood fasting plasma glucose, fasting insulin and glycosylated hemoglobin levels were reduced (P < 0.05), the blood total cholesterol, triglyceride and low-density lipoprotein cholesterol levels were decreased (P < 0.05), the serum C-reactive protein, tumor necrosis factor α and interleukin 6 levels were decreased (P < 0.05), the serum malondialdehyde level was reduced (P < 0.05), and the serum superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05). In conclusion, CPP can alleviate the T2DM in rats, which may be related to its resisting inflammatory response and oxidative stress in body.
Highlights
Type 2 diabetes mellitus (T2DM) is a non-insulin dependent diabetes mellitus, which is caused by the decrease in glucose metabolism regulation ability of insulin accompanied by islet β cell dysfunction (Olokoba et al, 2012)
This study investigated the effect of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides (CPP) on the glucose-lipid metabolism in T2DM rats and the mechanisms related to inflammatory response and oxidative stress
The rats in CPP‐1, CPP-2 and CPP-3 groups had similar symptoms, but the degree was lighter than the model group
Summary
Type 2 diabetes mellitus (T2DM) is a non-insulin dependent diabetes mellitus, which is caused by the decrease in glucose metabolism regulation ability of insulin accompanied by islet β cell dysfunction (Olokoba et al, 2012). Insulin resistance and insulin secretion disorder are the main pathological features of T2DM, but the specific mechanism is still unclear (Cavaghan et al, 2000). The cytokine‐mediated inflammatory response plays an important role in the impaired glucose tolerance and T2DM, and the concentration of a variety of inflammatory factors will increase with the progress of the disease (Diakakis et al, 2005; van Doorn et al, 2006; Ruotsalainen et al, 2006; Tatsch et al, 2015). The oxidative stress is closely related to the insulin resistance and insulin secretion dysfunction which determine the progress of T2DM (Tangvarasittichai, 2015; Rehman & Akash, 2017). Cyclocarya paliurus (Batal.) Iljinskaja belongs to the dicotyledneae family. It is one of the unique species of plants in China, and is one of the most endangered plants. Polysaccharides are the main physiological active substance in Cyclocarya paliurus (Batal.) Iljinskaja, which have aroused great interests and widespread concerns (Xie et al, 2010; Xie et al, 2014;)
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