Abstract
A 22-residue cyclic peptide with a 56-atom (18-residue) intramolecular disulfide has been synthesized on solid phase. Two synthetic schemes, based on Boc/benzyl chemistry and either acetamidomethyl (Acm) or 9-fluorenylmethyl (Fm) groups for cysteine protection, have been compared. The deprotection-oxidation of both S-protecting groups has been explored under several experimental conditions. The most successful route involved on-the-resin disulfide formation via Cys(Fm) deprotection-oxidation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
